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Others may need medical nutrition therapy, obesity medicines, endoscopic options or bariatric surgery depending on their BMI, eating behaviour, diabetes status, sleep issues and long-term weight history

Chemical modifications, such as amino acid mutations, addition of fatty acid chains, or design of synthetic analogs, can enhance their resistance to enzymatic degradation and significantly improve metabolic stability and half-life (Yu et al., 2018

And weeks 36 through 48 approached a plateau in most participants, with weight either stabilizing or declining very slowly

Physiol Behav (2010) 101:4552