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The United States, in particular, has seen an increased adoption of GLP-1 receptor agonists like semaglutide and tirzepatide, contributing to a robust market presence

Interestingly, while administration of GEP12 did not result in a reduction in GLP-1R internalization, when evaluated in the presence of a Y1-R antagonist, it elicited increased insulin secretion in rat islets compared to results obtained with either GEP44 or Ex-4

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The shedding often becomes noticeable two to four months after starting treatment or after significant weight loss, which is a key distinguishing feature