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RCT: Randomized Controlled Trial
But the drugs are extremely expensive, and many insurance companies do not cover the medications when patients use them to lose weight rather than to control diabetes
When liraglutide binds to GLP-1R on GABAergic neurons in the NTS, it directly potentiates GABA release and suppresses food intake (Fortin et al., 2020)
Additionally, long-term pharmacotherapy might be necessary, as stopping medication often leads to a loss of GLP-1RA benefits, even with continued lifestyle changes (Rubino et al
