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After each injection, the medication gradually releases into the bloodstream and influences the brain centers responsible for hunger and satiety

Meta-analyses of randomised controlled trials (RCTs) also confirm that energy-restricted MD interventions yield greater weight loss than control or low-fat diets, particularly when combined with increased physical activity [116]

doi: 10.1186/1741-7015-11-8 26 HayDLChenSLutzTAParkesDGRothJD

1 Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck MA, Nissen SE, Pocock S, Poulter NR, Ravn LS, Steinberg WM, Stockner M, Zinman B, Bergenstal RM, Buse JB

Evidence for altered transport of insulin across the blood-brain barrier in insulin-resistant humans