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New evidence suggests semaglutide may provide direct liver protection in MASH through intrahepatic GLP-1 receptors, adding to the growing evidence of organ specific benefits seen in the heart and kidneys

Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem

Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation

12 These effects could be secondary to reduced hepatic lipogenesis, increased fatty acid oxidation and modulation of lipoprotein metabolism

Reduced inflammation may be one of the reasons, including weight loss and better blood sugar control, why