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Monthly loss depends on baseline weight, age, sex, concurrent medications, dietary adherence, physical activity, insulin sensitivity, and gastrointestinal tolerance

The GTP-bound -subunit dissociates from the trimer and activates adenylyl cyclase, which in turn produces large amounts of cyclic AMP (cAMP) from ATP within the cell

Understanding these pharmacological properties helps clarify why patients experience specific effects during treatment, including changes in hunger and satiety signals

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