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Authors relationships and activities HK received grants from Ono Pharmaceutical Co., Taisho Pharmaceutical Co

Worsening Common Side Effects Excessive drinking can worsen the common Wegovy side effects, including nausea, vomiting, stomach upset, headache, and fatigue

It signals fullness through GLP-1 receptors in the hypothalamus and brainstem, which patients describe as the quieting of food noise, connected to the psychology around overeating and resultant weight gain

Efficacy at .25 mg is typically modest because this dose is sub-therapeutic for most patientsit exists to assess tolerability and allow the body to adapt to GLP-1 agonism

The most significant anatomical risk factor is a small optic disc with a small or absent physiologic cup, often referred to as a "disc at risk." This structural variant reduces the space available for the optic nerve fibers and may predispose to ischemic events