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You can inject into: The abdomen, at least 2 inches away from your belly button The outer thigh, either the front or side of the leg The back of the upper arm if someone is helping you Rotate injection sites each week to help minimize irritation and ensure consistent absorption

Two propensity score matched observational studies have been conducted to date, either evaluating suicidality risk in patients using semaglutide vs non-GLP-1RA glucose-lowering agents, or in those using any GLP-1RA vs users of dipeptidyl peptidase-4 (DPP-4) inhibitors

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Clinical Category Guidance & Safety Mandates Thyroid History Alert Do not use if you or any family members have a history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

In parallel, glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide and tirzepatide, have transformed the therapeutic landscape of T2D and obesity by producing profound weight reduction, improvements in glycemic control, and cardiovascular risk reduction [7,8]