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10.1186/s13287-017-0694-z Summary Keywords GLP-1, GLP-1RAs, T2DM, glucose, mechanism Citation He X, Zhao W, Li P, Zhang Y, Li G, Su H, Lu B and Pang Z (2025) Research progress of GLP-1RAs in the treatment of type 2 diabetes mellitus

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GLP-1 and GIP receptor agonists work by increasing the amount of insulin that the pancreas releases in response to food, while decreasing the amount of sugar the liver releases into the blood and slows food leaving the stomach after eating

In that study, the GLP-1 group showed greater improvement in sperm count, motility, and morphologythe percentage of sperm with normal shapethan the comparison groups

2025 ( Diabetes Obesity and Metabolism ), Global pharmacovigilance database analysis of adverse drug reactions in GLP-1RAs approved for obesity