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Despite this mild increase in heart rate, large-scale cardiovascular outcome trials have consistently demonstrated robust major adverse cardiovascular event (MACE) reductions, indicating that this mild tachycardia does not translate to increased cardiovascular risk for most subjects

Dipeptidyl peptidase 4 inhibitors prevent the inactivation of GLP-1 and GLP-2, leading to elevated levels of GLP-1 and GLP-2 both after meals and during fasting (45)

Big Pharma made synthetic versions
