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20 In another open-label trial, Li and colleagues 22 assessed the effects of liraglutide on cognitive functioning

Moreover, approximately 60% of patients randomized to high dose retatrutide (8-12mg) lost 15% of weight compared with 2% with placebo [4]

Most tirzepatide injection site reactions are mild to moderate and resolve spontaneously within 2-3 days without requiring treatment

Adults with overweight and a comorbidity In adults with overweight (defined as a BMI of 27 kg/m 2 to 30 kg/m 2 ) and type 2 diabetes, CVD, hypertension, obstructive sleep apnea or dyslipidemia, ACP recommends semaglutide and tirzepatide as first-line treatments and liraglutide as a second-line treatment

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