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In general, GLP-1RAs provides a highly effective and well-tolerated treatment regimen to help obese patients lose weight while improving weight-related complications ( FIGURE 6 5 Application of GLP-1RAs in T2DM GLP-1RAs can be divided into two categories: animal GLP-1 and its derivatives and human GLP-1 and its derivatives, which has experienced a development process from short-acting to long-acting to ultra-long-acting (Ji, 2022)

Altamimi, M., et al

The Limitations You Should Know: Dependency, Cost, and Side Effects Despite benefits, GLP-1 medications present challenges such as dependency, rebound weight gain upon stopping treatments, high costs especially in emerging markets, and side effects like nausea or digestive discomfort

Outcome data and main results Obstetric complications in the GLP-1 RA-exposed vs

Scientists from the WHO recently wrote: The approval of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for the treatment of obesity creates potential for a transformation of the whole health system that could halt and reverse the global obesity pandemic through prevention and effective integrated management. Growing crisis South Africa is grappling with dual diabetes and obesity epidemics, on top of the HIV and TB epidemics, but is not responding effectively, resulting in high obesity and diabetes-related deaths