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Afonina IS, Zhong Z, Karin M, Beyaert R

Many of them have been used in weight-loss teas, pills, and powders for decades, in some cases even longer than GLP-1 medications, yet they have never caused a true breakthrough in weight-loss treatment

While some data points to a potential risk, other research highlights the metabolic benefits these medications provide

Early retrospective studies in patients with IBD suggest improved clinical outcomes, such as reduced hospitalization and surgery rates, particularly in those with obesity

In this context, the aim of the present document is to summarize, in the form of a narrative literature review, the currently available data on the main mechanisms of action of GIP/GLP-1 co-agonists and the clinical effects of tirzepatide evaluated in various clinical trials