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Although Glp1r mRNA transcripts are detected in whole heart extracts such methods do not distinguish between vascular smooth muscle cells or atrial cardiomyocytes, there were technical difficulties in isolating pure cardiomyocyte populations from the ventricle without contamination of atrial cardiomyocytes isolated from neonatal mouse [36]

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Tirzepatide, a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA), has shown superior efficacy in glycemic control, weight loss and cardiometabolic outcomes compared to GLP-1 agonists alone

[DOI] [PubMed] [Google Scholar] 128.Dahl D, Onishi Y, Norwood P, Huh R, Bray R, Patel H, et al

Weight loss and lifestyle intervention for cardiorespiratory fitness in obstructive sleep apnea: the INTERAPNEA trial