why does semaglutide work Benefits of GLP-1 in Coral Gables & Pinecrest FL How Long Does It Take

Lancet 2009;374:3947

The findings challenge the assumption that weight loss is the primary mechanism by which semaglutide confers cardiovascular protection

Optimizing Weight Loss Efficacy Clinical studies have indicated that tirzepatide, with its dual GLP-1 and GIP agonism, may lead to greater average weight loss percentages compared to semaglutide in certain populations

Tirzepatide also significantly reduced the sleep apnoea-specific hypoxic burden, a measure that comprises the frequency, duration and depth of oxygen desaturation associated with sleep events, and is considered a better predictor of cardiovascular risk and mortality in sleep apnoea

The causality is unclear, and confounding factors are significant, but it raises a flag that needs further investigation