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However, in the striatum, which is located in the subcortical forebrain, insulin influences dopamine reuptake and release, with IR opposing these effects, impacting neuronal excitatory projections [90]

These findings suggest that, in addition to its role in modulating immune responses, exenatide confers neuroprotection by alleviating ER stress, thus preserving cellular integrity and supporting functional recovery

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Convergent evidence shows that (i) obesity is associated with reduced striatal D2 receptor availability [27], (ii) high-glycemic/rapid-absorption carbohydrates are plausible pharmacokinetic drivers of addictive-like responses [25], and (iii) ultra-processed foods high in refined carbohydrates and/or fat are disproportionately linked to addictive-like eating behaviors [28]