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Description
70 In the STEP HFpEF trial, higher changes in KCCQ-CSS were linearly associated with weight loss with semaglutide (5.9-point increase in KCCQ-CSS per 10% body weight loss)
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The escalation period extended over several months, with participants reaching maximum doses around week 20-24 in most protocols
It suggests that glucagon receptor activation may require reaching a specific concentration threshold to produce meaningful metabolic effects
Roughly half had never thought about cosmetic work until their weight loss changed the face they saw in the mirror
