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N Engl J Med 2005;353:2643-53.ArticlePubMedPMC 111
Slower-than-expected progress is a common concern, particularly in the early stages of treatment
The mean age at initiation of treatment was 21.4 with a minimum age of 12 and a maximum of 47
Although the effects of MMPs on tumor cells vary depending on the specific MMP subtype, tumor type, and patient characteristics, studies indicate that decreased MMP expression is strongly associated with the inhibition of tumor cell metastasis [85, 86]
