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Common nutritional concerns associated with GLP-1 therapy may include: Reduced appetite and inadequate nutrient intake Loss of lean muscle mass during rapid weight reduction Nausea, digestive discomfort, and poor food tolerance Fatigue and reduced energy levels Micronutrient deficiencies over long-term use Increased nutritional needs in patients with complex clinical conditions Effective GLP-1 treatment requires more than medication alone

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A 2026 review of six studies found that people with diabetes or obesity taking GLP-1 medications were prone to developing a number of nutrient deficiencies, particularly in vitamin D, iron, and B v...