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W., & Phillips, S

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The SURPASS program, which evaluated tirzepatide in patients with type 2 diabetes across diverse treatment settings, consistently showed superior reductions in glycated hemoglobin compared with established therapies, including basal insulin and selective GLP 1 receptor agonists

A total of 453 RCTs involving patients with T2DM were included, evaluating nine classes of glucose-lowering drugs (metformin, sulfonylureas, pioglitazone, DPP-4 inhibitors, GLP-1 RAs, SGLT2 inhibitors, insulin, alpha-glucosidase inhibitors, and meglitinides) with reported outcomes on glycemic control, mortality, and incidence of CVD

Tapering rather than stopping cold turkey, combined with sustained behavioral changes, helps minimize rebound weight
