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Both subjects had viral RNA shedding levels 25), chronic lung disease (including asthma), chronic kidney disease, current smoker, immunosuppressive disease or immunosuppressive treatment, cardiovascular disease, hypertension, sickle cell disease, neurodevelopmental disorders, active cancer, medically-related technological dependence, or were 60 years of age and older regardless of comorbidities

H2020107005 & H2020107002) and the Scientific and Technological Project of the Hebei Province of China (Grant No