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Preclinical studies suggest that GLP-1 and its analogs may exert direct effects on the hypothalamicpituitarygonadal (HPG) axis, thereby modulating reproductive function

Contact your GP to discuss symptom management strategies, potential dose adjustments, or additional reflux medications before discontinuing treatment

Weight loss is achieved in those who have a calorie deficit, meaning more calories are being burned than the amount of calories being eaten in a given day

It plays a crucial role in glucose homeostasis by: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner [8] [9] Suppressing glucagon release , thereby reducing hepatic glucose production Slowing gastric emptying , which moderates postprandial glucose excursions Promoting satiety through actions on appetite centres in the brain GLP-1 receptor agonists mimic these physiological effects but with extended half-lives, allowing for once-weekly or once-daily administration

Whether using an SGLT-2 inhibitor or a GLP-1RA, metformin should always be considered as first-line therapy for T2DM to reduce insulin resistance