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Notice that at 5 mg/mL, reaching even the standard starting dose of 2.5 mg requires drawing 50 units, which is half a milliliter
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De esta forma, el frmaco acta sobre los receptores del cerebro que controlan el apetito ayudando a comer menos y reduciendo el peso corporal
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However, native GLP-1 is always easily degraded by dipetidylpeptidase IV (DPP IV) to produce some N-terminally truncated metabolites in vivo, followed by rapid clearance (half-life is around 2 min), preventing its broad applications 8
