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Keywords: central nervous system, anorexic medications, sympathetic nervous system, chronic heart failure Introduction Type 2 diabetes mellitus (T2DM) and obesity are major public health problems affecting millions of people worldwide

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Furthermore, challenges such as low drug concentration at the local pathological site after systemic administration, limited target specificity and short drug half-life persist [6]

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doi: 10.1067/mpd.2000.106563 193 KhanMJGerasimidisKEdwardsCAShaikhMG

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