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In addition to renal outcomes, SGLT2 inhibitors also contribute to modest weight loss and blood pressure reduction

Nissen says its results are likely to steer prescribers and patients toward favoring a dual agonist like tirzepatide

Although Amgen did not disclose many details, management was encouraged enough to announce that the program will move to phase 3 in obesity, obesity-related indications, and diabetes, an area where theoretical concerns about blood sugar effects of the drug had previously made development less appealing

Physiological Reviews , 87(4), 14091439