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Patients taking GLP-1 agonists most commonly complain of gastrointestinal effects, 2 such as unsettled stomach, upset GI tract, variable bowel movements or trouble with elimination, abdominal discomfort, and gastroesophageal discomfort

Inclusion and exclusion criteria All studies published as full-text articles in indexed journals, covering all levels of evidence and examining retatrutide globally from their inception, were included

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PlexusDx does not sell, prescribe, or recommend any other therapeutic peptide in the GLP-1 category beyond semaglutide and tirzepatide pathways, including dulaglutide, liraglutide, retatrutide, cagrilintide, and related compounds

With those samples, we performed immunofluorescence staining for ENaC and AQP2