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41 According to mouse and human studies, ACBP is overexpressed in obesity, and inhibiting ACBP expression suppresses appetite and leads to weight reduction, making it a promising target for obesity treatment

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A comprehensive analysis of 43,365 individuals from two US healthcare databases indicated that GLP-1 RAs do not elevate the risk of pulmonary aspiration during upper gastrointestinal endoscopy in patients with T2DM when compared to SGLT-2 inhibitors, yielding a pooled risk ratio of 0.98 (95% CI, 0.73 to 1.31) among GLP-1 RA users

Semaglutide also lowers blood pressure, reduces systemic inflammation marked by C-reactive protein, and improves insulin sensitivityall factors that protect against cardiovascular disease