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Metformin Metformin is also being explored for its potential anti-aging effects

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5.4 Hypoglycemia Insulin and insulin secretagogues are known to cause hypoglycemia
When Semaglutide is taken with insulin, and the insulin dose is reduced too quickly, it can lead to high blood sugar (hyperglycemia), which increases the risk of diabetic ketoacidosis

The latter must be evaluated in well-designed clinical trials, which is itself challenging
