gip and glp-1 agonist Receptor Agonism Attenuates Receptor Induced Nausea Emesis in Preclinical Models — Hayes Lab GLP-1 Receptor Agonists Explained for
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[DOI] [PubMed] [Google Scholar] 122.Xie Y., Choi T., Al-Aly Z

(13) A key mechanism through which GLP-1 receptor agonists may influence bone metabolism is the osteoprotegerin (OPG)/RANKL/RANK pathway, which regulates osteoclast differentiation and bone resorption
This results in increased stimulation of anorexigenic POMC/CART neurones and decreased activity of orexigenic NPY/AgRP neurones, profoundly altering appetite signals (Trapp and Brierley 2022)

A gastrointestinal (GI) hormone, GLP-1, and a gastric inhibitory peptide, GIP, are secreted in response to food consumption
Montrose-Rafizadeh et al., 1994
