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GLP-1 receptor agonism is well established to slow gastric emptying, which can increase intra-gastric pressure and potentially promote acid reflux in susceptible individuals

For semaglutide, this translates to a clearance period of approximately 5 weeks after the final dose

She had started semaglutide six weeks prior for weight loss and began experiencing nausea, shortness of breath, and chest discomfort three weeks after initiation

Because these peptides represent a fundamental shift in how we approach body composition, metabolic health, and longevity

Advisory committees rarely derail drugs that have strong efficacy data