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(44) reported that both GIPR agonist (GIPRA) and dual GIP/GLP-1 receptor agonist similarly improved glucose tolerance in GLP-1R knockout mice, but not in dual incretin receptor knockout mice

mean duration of type 2 diabetes, 14.9 years)

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Hypoglycemia awareness Tight glycemic control is a risk factor for impaired glucose counter-regulation and hypoglycemia unawareness lower levels of HbA1c result in a resetting of thresholds for the counter-regulatory and symptomatic responses to hypoglycemia at lower glucose concentrations
