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We discussed the leading theory behind why GLP-1s can reduce addiction, his opinion of the recent Lancet trial, and what it will take for these drugs to be widely adopted as treatments for substance use disorders

And research like this brings us one step closer to that vision

Clinical trials show Retatrutide delivers 24.2% weight loss

Retatrutide is an investigational triple receptor agonist targeting GLP-1, GIP, and glucagon receptors, not yet licensed by the MHRA or EMA, with Phase 2 data showing substantial weight reduction over 48 weeks

In clinical studies, people using GLP-1 medications (especially at higher, weight-loss-approved doses like Wegovy) lost 1520% of their body weight on average over a year, alongside diet and lifestyle changes