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ClinicalTrials.gov record NCT03998514 for CB4211, a MOTS-c analog studied in Phase 1a/1b trials

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thus, these agents are useful for controlling postprandial hyperglycemia.86 Insulin degludec has an ultra-long lasting effect and a stable pharmacokinetic profile

But the doses required (typically 5001,500 mg of berberine per day) are far beyond what a small patch can plausibly deliver through the skin, even before you account for the absorption barrier