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1 Dose strength Rybelsus: lowmoderate daily doses for glucose control Oral Wegovy: much higher daily dose to match injectable Wegovy exposure With oral bioavailability at ~1%, obesity efficacy simply requires more drug not interchangeable
BCBS Michigan cites concerns about safety, effectiveness, and cost for this decision
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This dominance, despite strong clinical efficacy, raises concerns regarding long-term safety, accessibility, and mechanistic diversity
