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Compared with active drugs, oral semaglutide was superior to empagliflozin in reducing total cholesterol and LDL [36] and was superior to sitagliptin in reducing total cholesterol, LDL, and TAGs [37, 41], but there was no significant difference when compared with another GLP-1 analogue (liraglutide) [38]

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This suggests that, to maintain weight loss, treatment for obesity should be considered chronic (as in the case of hypertension), rather than as a short course of treatment associated with acute illnesses [9, 55]

The study appears in According to the GLP-1 drugs also improve blood flow to the heart and act directly on the hypothalamus to increase the sensation of being full after a meal

Blood Pressure-Lowering Effects of SGLT2 Inhibitors and GLP-1 Receptor Agonists