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Efficacy and safety of sitagliptin as compared with glimepiride in Japanese patients with type 2 diabetes mellitus aged 60 years (START-J trial)

GLP-1 medications lead to reduced caloric intake, which can affect breast milk supply

the cohort included 13,204 GLP-1 RA users and 13,204 nonusers.The researchers observed associations for GLP-1 RA use with lower risks for stroke/transient ischemic attack, pulmonary embolism, venous thromboembolism, emergency department visits, and mortality (hazard ratios, 0.87, 0.69, 0.83, 0.79, and 0.56, respectively)."As an obesity medicine physician scientist who regularly cares for patients with complex inflammatory conditions, this study reinforces what many of us have suspected clinically -- that the benefits of GLP-1 receptor agonists extend well beyond blood sugar control and weight loss and may fundamentally alter the disease trajectory for some of our highest-risk patients," Fatima Cody Stanford, M.D., M.P.H., member of the American Heart Association Lifestyle and Cardiometabolic Council, said in a statement.Abstract/Full TextMore Information.Sign up for our weekly HealthDay newsletter

The push is equally severe from regulations too

Weight loss follows a progressive pattern, with 35% reduction by 12 weeks and potentially 1015% or more by 612 months in responders
