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And, based on the data so far, a significantly larger effect size than anything that came before

Variants in GLP1R (the GLP-1 receptor itself), GIPR (rs1800437 is the headline variant for differential GLP-1 response), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with measurably different response patterns to semaglutide and tirzepatide

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As the prevalence of these metabolic disorders continues to rise, the GLP-1 receptor agonist market is set for substantial growth in the coming years

[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Filippatos TD, Panagiotopoulou TV, Elisaf MS