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Other tested variants include GIPR rs1800437 (involved in glucose-dependent insulin secretion), FTO rs9939609 (fat mass regulation), and MC4R rs17782313 (melanocortin pathway signaling)

Digestive side effects are a common experience for many patients starting these medications

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In reality, up to 70% of patients stop GLP-1 treatment within a year most often due to: High cost (GLP-1s can cost $1,000+ per month without insurance) Loss of insurance coverage for weight loss treatment Side effects such as nausea, diarrhea, constipation, or fatigue A Misconceptions some patients stop once they lose initial weight, believing they no longer need the medication 2

Factors such as smoking, cholesterol, blood pressure, and diabetes shifted from vague ideas to measurable predictors