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Part of this is because people can initially lose some water weight, and then lose some muscle that helps burn calories

Proteins are notoriously fragile

When GLP-1 reaches the pancreas, it binds to GLP-1 receptors (GLP-1R) expressed on the pancreatic cells, stimulating insulin release

Conley TE, White KL, Bond A, et al
Increased adiposity drives insulin resistance The prevalence of insulin resistance and type 2 diabetes has experienced a significant surge within the US population in the past 20 years
