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Until further evidence is provided, GLP-1 RAs will likely be used preferentially in patients with cardiovascular disease or cardiovascular risk factors

Pancreatitis In our meta-analysis of nine RCTs, six trials reported pancreatitis events that occurred during the study period

Discontinuation protocols When discontinuation becomes necessary, whether due to side effects, cost, pregnancy planning, or personal preference, abrupt cessation causes rapid weight regain in most individuals

and (2) the change from baseline to 52 weeks in the Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CSS

Although usually short-lived, frequent diarrhoea can lead to dehydration