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Pyruvate tolerance was assessed in 12 h-fasted mice injected intraperitoneally with 1.25 g kg 1 sodium pyruvate (11360070, Thermo Fisher)

Interestingly, we found that, whilst exendin-4-induced SNAP-GLP-1R internalization was delayed in -arrestin-less vs

Despite substantial mechanistic and preclinical evidence indicating neuroprotective effects, translating these findings into clinical benefits has proven challenging

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GLP-1 drugs specifically affect reward processing by reducing the activity of dopamine neurons