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Unlike GLP-1, exendin-4 has a glycine at the second amino acid position at the N-terminus, which protects the peptide from DPP-4-mediated degradation and inactivation

For titration protocols, reconstitution instructions, and dosing calculations, see our guide: Retatrutide Dosing Guide: Full Dosing Chart & Calculator

Vaduganathan M, Docherty KF, Claggett BL, Jhund PS, de Boer RA, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, et al

Fluids and electrolytes: this is hugely underrated

Some common side effects may include mild nausea, vomiting, or digestive discomfort, especially during the initial stages of treatment