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5 Given the substantial clinical and economic burden of obesity, the development and implementation of effective therapeutic strategies are imperative to mitigate the incidence of obesity-related comorbidities

Patients who previously consumed high-fat diets may need to make substantial adjustments, but these modifications typically become easier as new eating patterns are established and weight loss progresses

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Most patients tolerate this combination without incident, but certain warning signs warrant immediate contact: severe or persistent nausea, vomiting, stomach pain, changes in mood or suicidal thoughts, or symptoms of serotonin syndrome (agitation, confusion, rapid heart rate, muscle rigidity, fever)