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The study will test efpeglenatide in patients whose blood sugar is not controlled well enough with metformin and dapagliflozin, an SGLT-2 inhibitor

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We recommend fasting for high-carbohydrate content clear liquids (10% glucose) for 8 h before procedures requiring anaesthesia for patients taking GLP-1 RAs without significant gastrointestinal symptoms (significant symptoms include severe nausea, vomiting, and inability to tolerate oral intake and do not include fullness or early satiety) (C)

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All c-Fos positive cells quantified were colocalized with DAPI