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Ligand specificity GLP-2 and GLP-1 share high sequence similarity (69.7%) and have almost identical residues in two regions: the N-terminus (first six residues in GLP-2) that penetrates into the TMD core, and the C-terminus (residues 1833) that is recognized by the ECD and ECL1 of the receptor

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Internet J Endocrinol

This warning stems from rodent studies that resulted in the animals developing thyroid C-cell tumors