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For example, when synthesized as double-chain (dc) peptides, the VILPs from Singapore Grouper Iridovirus (SGIV) and Grouper Iridovirus (GIV) not only act as insulin analogs in vitro and in vivo, but dcGIV-VILP also exhibits preferential tissue-specific action to stimulate glucose uptake in white adipose tissue 28

The cardiovascular outcomes trial (TRIUMPH CVOT) is expected to continue through 2028 and may influence labeling decisions, though it is not expected to delay initial approval