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Volz A, Gke R, Lankat-Buttgereit B, Fehmann HC, Bode HP, Gke B

A consistent pattern emerges in phenotypes with a high metabolic burden, such as obesity and IGT or pre-diabetes, improvements in fasting glucose, OGTT curves, and HbA1c are more pronounced, with some subjects even reverting from IGT to normoglycemia

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While not a universal solution, their pleiotropic effects on central and peripheral pathways render them uniquely suited for addressing the complex interplay of metabolic and neuropsychiatric factors in SUDs