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Evidence Snapshot The STEP trials demonstrated significant weight reduction with semaglutide, with gastrointestinal side effects most prominent during dose escalation. Long-term micronutrient outcomes were not primary endpoints

Along with causing a significant reduction in the size of testes with testicular degeneration, zuclomiphene also caused Leydig cell loss, an absence of sperm in the seminiferous tubules, and a reduction in size of the epididymis, seminal vesicles, and kidneys

However, its effects go beyond diabetes management

GPs in England will start offering semaglutide to some patients through a two-year 40m pilot scheme the Prime Minister hopes will help tackle obesity and cut NHS waiting lists

The smallest country in Central America geographically, El Salvador has the fourth largest economy in the region