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10 Recently, several clinical trials have shown the potential effects of these medications in not only in glycemic control but also in the improvement of cardiovascular outcomes, weight loss, osteoarthritis, 11 metabolic dysfunctionassociated steatohepatitis (MASH), 12 Parkinsons disease, 13 chronic kidney disease (CKD) 14 and obstructive sleep apnea

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Common side effects include: Nausea Vomiting Diarrhoea Constipation These are usually mild and tend to improve over time, especially when the dose is increased gradually

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Conversely, strong CYP3A inducers (such as rifampin, phenytoin, and carbamazepine) could reduce orforglipron exposure below therapeutic levels