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Participants treated with liraglutide (239), semaglutide (240), or tirzepatide (200) in the clinical trials had a percent reduction in fat mass approximately three times greater than the reduction in lean mass, leading to an overall improvement in body composition

Elsevier, 2022

What is a GLP-1 journey really like

The ISA study included approximately N = 353 AI participants aged 18-75 years, who were residents of Osage Nation, and classified as overweight and obese according to BMI criteria

Weight and anthropometric outcomes Percentage weight loss The average percentage weight-loss trajectories with semaglutide and placebo over 4 years of observation are shown in Fig